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Similarly, during weeks 9 to 52, the continuous abstinence rate was 22% to 23% with varenicline compared with 15% to 16% with bupropion and 8% to 10% with placebo.

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The foregoing applications, owned in common with the present application and incorporated herein by reference in their entirety, generically recite pharmaceutically acceptable acid addition salts for the compounds referred to therein.

Varenicline is an alpha-4 beta-2 neuronal nicotinic acetylcholine receptor partial agonist.

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To further investigate functional differences between these partial agonists, we utilized voltage-sensitive dye imaging (VSDi) in ventral hippocampal slices to determine the effects of sazetidine-A and varenicline in animals chronically treated with saline, nicotine, or undergoing 24 h withdrawal.

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Additionally, the chronic nicotine treatment group as well as administration of sazetidine-A (0.

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Cardiovascular events often occurred as frequently in the placebo and nicotine replacement arms as in the varenicline arm and overall were rare.

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These identical double-blind studies compared CHANTIX 2 mg per day, bupropion sustained-release (SR) 150 mg twice daily, and placebo.

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Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area.

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Find substitutes -- sugarless gum to chew or a pen or pencil to hold -- and change your routines to avoid triggering a desire for tobacco.

Also tell your doctor about any history of depression or other mental health problems before taking CHANTIX, as these symptoms may worsen while taking CHANTIX.

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Another benefit from this work is that in the future, when we possess a greater knowledge of psychiatric illness mutations, we may be able to predict which individuals are at risk of illness before they develop it or tailor appropriate medicine to subsets of patients.

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